Background: Oral mucosal lesions represent a significant burden in clinical practice, often requiring effective management strategies. Laser therapy has emerged as a promising modality for treating such lesions. This study aims to evaluate the effectiveness of laser therapy in the management of oral mucosal lesions. Materials and methods: A retrospective analysis was conducted on patients presenting with various oral mucosal lesions who underwent laser therapy at a tertiary dental clinic over one year. Data regarding lesion characteristics, treatment parameters, and outcomes were collected and analyzed. Lesion size reduction, pain scores, and patient satisfaction were among the parameters assessed. Results: A total of 50 patients with oral mucosal lesions were included in the study. Laser therapy resulted in a mean reduction in lesion size of 60% ± 10% (mean ± standard deviation). Pain scores decreased significantly from an average of 7.5 ± 1.2 to 3.2 ± 0.8 posttreatment (p < 0.001). Additionally, 80% of patients reported high satisfaction with the outcomes of laser therapy. Conclusion: Laser therapy demonstrates effectiveness in the management of oral mucosal lesions, as evidenced by a significant reduction in lesion size, alleviation of pain, and high patient satisfaction rates. It represents a valuable therapeutic option for clinicians managing such lesions.