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VOLUME 1 , ISSUE 1 ( January-June, 2024 ) > List of Articles


Efficacy of Daphne Indica 1X Homeo Tablets for Smoking De-addiction: A Placebo-controlled Study

Rahul Srivastava, Ananya Singh, Lynn Johnson

Keywords : Adjunctive therapy, Daphne Indica, Homeopathy, Smoking cessation, Tobacco addiction

Citation Information : Srivastava R, Singh A, Johnson L. Efficacy of Daphne Indica 1X Homeo Tablets for Smoking De-addiction: A Placebo-controlled Study. J Dent bio allied Health Sci 2024; 1 (1):1-5.

DOI: 10.5005/jdbahs-11017-0002

License: CC BY-NC 4.0

Published Online: 19-06-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Aim and background: Tobacco addiction poses a significant public health challenge globally, necessitating effective smoking cessation interventions. Homeopathic remedies, such as Daphne Indica 1X tablets, have emerged as potential adjunctive therapies for tobacco de-addiction due to their purported anti-addictive properties. However, evidence supporting their efficacy remains limited. Materials and methods: In this randomized controlled trial, we evaluated the efficacy of Daphne Indica 1X tablets in facilitating smoking cessation among adult smokers. Participants (n = 200) were randomly assigned to receive either Daphne Indica 1X tablets or a placebo for 12 weeks. Biochemically verified abstinence rates, self-reported smoking cravings, and changes in daily cigarette consumption were assessed at baseline and 12 weeks. Results: Participants receiving Daphne Indica 1X tablets demonstrated higher rates of biochemically verified abstinence (35 vs 20%) and self-reported smoking cessation (50 vs 35%) compared to the control group. Additionally, the intervention group exhibited significant reductions in smoking cravings and daily cigarette consumption compared to baseline. Conclusion: Our findings suggest that Daphne Indica 1X tablets may be a promising adjunctive therapy for tobacco de-addiction. Further research is warranted to confirm these results and elucidate the underlying mechanisms of action. Integrating Daphne Indica into comprehensive smoking cessation programs may offer a holistic approach to addressing nicotine addiction and improving long-term health outcomes.

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  1. Centers for Disease Control and Prevention (CDC). Smoking & Tobacco Use: Health Effects of Cigarette Smoking. 2022. Available at:
  2. U.S. Department of Health and Human Services. The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health. 2014. Available from:
  3. Fiore MC, Jaén CR, Baker TB, et al. Treating tobacco use and dependence: 2008 update. Clinical practice guideline. Rockville, MD: U.S. Department of Health and Human Services. Public Health Service. Available from:
  4. Kapoor S, Dhankhar A, Bhatt G, et al. Complementary and alternative medicine/therapy for tobacco cessation in India: A secondary analysis of GATS-1 and 2. Indian J Community Med 2024;49(1):144–151. DOI: 10.4103/ijcm.ijcm_188_23.
  5. Shankar D, Rawat A. Daphne indica: A Review. Pharmacogn Rev 2010;4(8):83–87. Available from:
  6. Upadhyay G, Koranga S, Pandey D, et al. Investigation on the phytochemical analysis and biological activity of daphne papyracea wall. ex Steud. Leaf extracts from kumaun himalaya. Letters in Applied NanoBioScience 2023;12(4):109. DOI:
  7. World Health Organization. Tobacco. 2020. Retrieved from
  8. Benowitz NL. Nicotine addiction. N Engl J Med 2010;362(24):2295–2303. DOI: 10.1056/NEJMra0809890.
  9. Kai H, Koine T, Baba M, et al. Pharmacological effects of Daphne genkwa and Chinese medical prescription, “Jyu-So-To”. Yakugaku Zasshi 2004;124(6):349–354. Japanese. DOI: 10.1248/yakushi.124.349.
  10. Steinsbekk A, Lüdtke R. Patients’ assessments of the effectiveness of homeopathic care in Norway: A prospective observational multicentre outcome study. Homeopathy 2005;94(1):10–16. DOI: 10.1016/j.homp.2004.11.016.
  11. Bornhoft G, Matthiessen PF. Homeopathy in healthcare: Effectiveness, appropriateness, safety, costs: An HTA report on homeopathy as part of the Swiss Complementary Medicine Evaluation Programme. Springer Science & Business Media. 2011, 1st Edition: pp. 159–192. DOI:
  12. Conti DV, Lee W, Li D, et al. Pharmacogenetics of nicotine addiction and treatment consortium. Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. Hum Mol Genet 2008;17(18):2834–2848. DOI: 10.1093/hmg/ddn181.
  13. Posadzki P, Alotaibi A, Ernst E. Adverse effects of homeopathy: A systematic review of published case reports and case series. Int J Clin Pract 2012;66(12):1178–1188. DOI: 10.1111/ijcp.12026.
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